Traveling by plane, train or car - the easiest and best ways to get to Alsace.
Lyon to Strasbourg is 495km/308mi (about 5 hours). You can take routes A36 straight there.
Brest to Strasbourg is 1070km/665mi (11 hours). You can take routes A4 or A5 in between the two cities.
Marseille to Strasbourg is 806km/501mi (8 hours). You can take route A7 to A36.
Lille to Strasbourg is 522km/324mi (5 hours). You can take route E411 to A4.
Paris to Strasbourg is 488km/303mi (5 hours). You can take route A4.
In general, from the north of France, take route A1 and then A26 until Reims , after which you can take A4 to Strasbourg.
If you're coming from the south take route A7 until Lyon, then follow A42 and A40 until Bourg-en-Bresse. Taking route A39 to A36 will get you to Besançon; you can continue to Mulhouse on route A35.